Blood glucose regulation using closed- and open-loop insulin delivery systems
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چکیده
منابع مشابه
Closed-Loop Insulin Delivery Using a Subcutaneous Glucose Sensor and Intraperitoneal Insulin Delivery
OBJECTIVE Attempts to build an artificial pancreas by using subcutaneous insulin delivery from a portable pump guided by an subcutaneous glucose sensor have encountered delays and variability of insulin absorption. We tested closed-loop intraperitoneal insulin infusion from an implanted pump driven by an subcutaneous glucose sensor via a proportional-integral-derivative (PID) algorithm. RESEA...
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Bio-Medical Instrumentation is an expanding and demanding area in which many fields are available to explore, among which diabetes is a main segment to address. Glucose and Insulin are both interrelated terms. Glucose is a sugar which provides energy to the cells. Insulin is a hormone which supports the absorption of glucose. The Glucose-Insulin regulation model is obtained by modifying the dyn...
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A differential equation model is formulated that describes the dynamics of glucose concentration in blood circulation. The model accounts for the intake of food, expenditure of calories and the control of glucose levels by insulin and glucagon. These and other hormones affect the blood glucose level in various ways. In this study only main effects are taken into consideration. Moreover, by maki...
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BACKGROUND In order to stave off deleterious complications of the disease, the ultimate task for people with diabetes is to maintain their blood glucose in euglycemic range. Despite technological advancements, conventional open-loop therapy often results in prolonged hyperglycemia and episodic hypoglycemia, in addition to necessitating carbohydrate counting, frequent glucose monitoring, and dru...
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A canonical optimal control problem for linear systems with timevarying coefficients is considered in the class of discrete controls. On the basis of linear programming methods, two primal and two dual methods of constructing optimal open-loop controls are proposed. A method of synthesis of optimal feedback control is described. Results are illustrated by a fourth-order problem; estimates of ef...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1979
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf01222977